“Dextran-based nanocarrier for bioactive peptide delivery” 

Nisa Patikarnmonthon funded by TRF

collaborated with Prof. Watanalai Panbangred (MU-OU:CRC and Department of Biotechnology)

2 different structure of nanocarriers, nanosphere (left) and nanocapsule (right). [http://www.medscape.com/viewarticle/734055_3]
Bioactive peptides are the small of polypeptides with 2-50 amino acids, with the ability to enhance the biological function in human body. These biomolecules can act as drug-like or hormone-like substance, with various type of activities such as anti-oxidative, anti-angiogenesis, anti-microbial, etc. Consumption of bioactive peptides can be benefit for health in medical or nutritional aspects, however, direct eating of these biomolecules might not be appropriated as they can be digested by proteolytic enzyme in the body, leading to reduction of their activity.

Improvement of bioactive peptides stability is required to maintain their function in human body. Among many options, polymeric particle can be used to form a protective shield for those bioactive peptides, which could enhance activeness of those biomolecules. This research aims to use the polymeric particle for encapsulating the bioactive peptides to provide protection from the enzymatic degradation and maintain their activities after being orally uptake in the body.

Keyword : drug delivery, dextran, nanoparticles, bioactive peptides


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