“Study of the dextran-based nanoparticle formation and stability under biological condition”

Supawadee Sungpao, Nisa Patikarnmonthon

Nanoparticle developed from biopolymers have raised extensive interest for drug carrier application. The important parameters of nanoparticle for effective drug carrier are loading capacity, cytotoxicity, biodegradability, ability to control drug release, delivery efficiency, and target specificity. The natural polymer commonly used for preparing nanoparticles are including natural hydrogel polymer such as cellulose, albumin, collagen, chitosan and dextran.

In previous work, modification of dextran by enzyme-catalyzed transesterification with vinyl laurate was done to increase the hydrophobicity of dextran. The modified dextran become amphiphilic which could be able to form nanoparticle. The aims of this work is to study the nanoparticle formation of vinyl laurate-dextran and to investigate the stability of modified dextran in biological condition by using modified dextran with the ratio of dextran and vinyl laurate of 1:2 and 1:4.




Keyword: nanoparticles, dextran, vinyl laurate